Lawrence Margerum headshot

Lawrence Margerum

Faculty Emeritus

Faculty Emeritus
Harney Science Center 355


Professor Margerum started his professional career at the Clorox Technical Center investigating bleach stable metal chelates. He spend four years at Nycomed Salutar Imaging in Sunnyvale leading a team of scientists developing a Gd(III) contrast agent for blood imaging. He joined USF as assistant professor of analytical and inorganic chemistry and is currently professor emeritus with continuing interests in chemical education.

Research Areas

  • Effect of Dendrimer Size and pH on the Binding of Metal Complexes using electrochemistry
  • Immobilized Dendrimers as Platforms for Multivalent Binding of Metal Ions using spectroscopy techniques and solid-phase synthesis
  • Implementing technology-based learning tools for chemical education (OWL, CPR, clickers in the classroom, POGIL)
  • Creating and testing Problem based learning labs utilizing Green Chemistry principles


  • PhD, University of North Carolina at Chapel Hill
  • Postdoctoral Fellow, UCLA

Selected Publications

  • Silica nanoparticles functionalized with polyamidoamine (PAMAM) dendrimers as platforms for photoluminescence (PL) sensing of copper and cyanide ions, Kateryna Gerrans, Alicia Luhrs, Clara Feider, Lawrence D. Margerum, Journal of Colloid and Interface Science, 470, 2016, 276–283.

  • PAMAM dendrimers on controlled pore glass: The effect of tethered dendrimer size and tethered affinity groups NTA and terpy on metal ion and indicator dye uptake, Cheng-Chi Chang, Matthew Greaney, Michelle Nguyen, Derek Moy, Chang Liu, Justin Dancer, Lawrence D. Margerum, Inorganica Chimica Acta, 2014, 409, 127-136

  • "Integrated Laboratory Project Using Cyclic Voltammetry," A. Kulczynska, R. Johnson, T. Frost and L. D. Margerum, J. Chem. Educ., 2011, 88, 801-805.

  • How Do Structure and Charge Affect Metal-Complex Binding to DNA? An Upper-Division Integrated Laboratory Project Using Cyclic Voltammetry, A. Kulczynska, R. Johnson, T. Frost and L. D. Margerum, J. Chem. Educ. 2011, 88, 801-805.

  • Indicator displacement assays for amino acids using Ni–NTA tethered to PAMAM dendrimers on controlled pore glass, M. J. Greaney, M. A. Nguyen, C.-C. Chang, A. Good and L. D. Margerum, Chem. Commun. (Cambridge, U. K.) 2010, 46, 5337-5339.

  • Effect of PAMAM Dendrimers on *Ru(bpy)32+ Emission Quenching by Ferrocyanide and on ANS Fluorescence: Quantitative Binding Parameters as a Function of Dendrimer Size, pH, and Buffer Composition  Frost, T.; Margerum, L. D. Macromolecules 2010, 43, 1218-1226.

  • "Copper(II) complexes of a biphenyl-based ligand: Tuning the needs of the metal with those of the ligand." Malachowski, M. R.; Kasto, A. S.; Adams, M. E.; Rheingold, A. L.; Zakharov, L. N.; Margerum, L. D.; Greaney, M. Polyhedron, 2009, 28, 393-397.

  • "Application of Calibrated Peer Review (CPR) writing assignments to enhance experiments with an environmental chemistry focus," Margerum, L. D.; Gulsrud, M.; Manlapez, R.; Rebong, R.; Love, A., J. Chem. Educ., 2007, 84, 292-294.

  • "Synthesis, structure, redox properties and azide binding for a series of biphenyl-based Cu(II) complexes," Chen, J.; Russo, R.; Chao, W.; Margerum, L. D.; Malachowski, M. R.; White, R.; Thawley, Z.; Thayer, A.; Rheingold, A. L.; Zakharov, L. N., Dalton Trans., 2007, 24, 2571-2579.

  • "Effect of PAMAM Dendrimer Size and pH on the Electrostatic Binding of Metal Complexes Using Cyclic Voltammetry," Kulczynska, A.; Frost, T.; Margerum, L. D., Macromolecules, 2006, 39, (21), 7372-7377.