Lawrence  Margerum

Lawrence Margerum


Dr. Margerum graduated from Dartmouth in 1980 with a BA in chemistry and a senior thesis for Dr. Russ Hughes in organometallic chemistry. He was also a quarterback on the Dartmouth Football team, earning All-Ivy honors as a senior punter. During the next 5 years, he was a graduate student under Dr. Tom Meyer and Dr. Royce Murray at the University of North Carolina. He completed the PhD in inorganic photochemistry and electrochemistry in 1985 and moved to UCLA for post-doctoral work under Dr. Joan Valentine (bio-inorganic chemistry).

Dr. Margerum started his professional career in 1987 at the Clorox Technical Center investigating such areas as bleach stable metal chelates. In 1991, he moved to Nycomed Salutar Imaging in Sunnyvale, CA, leading a team of scientists developing a Gd(III) contrast agent for blood imaging. In 1995, he joined USF as assistant professor of analytical and inorganic chemistry. He currently has undergraduate and masters students exploring the following research areas:
- The Effect of Dendrimer Size and pH on the Binding of Metal Complexes using electrochemistry.
- Immobilized Dendrimers as Platforms for Multivalent Binding of Metal Ions using spectroscopy techniques and solid-phase synthesis.
- Implementing technology-based learning tools for chemical education (OWL, CPR, clickers in the classroom, POGIL).

He teaches courses in general, analytical and inorganic chemistry.

Recent Publications:
- " PAMAM dendrimers on controlled pore glass: The effect of tethered dendrimer size and tethered affinity groups NTA and terpy on metal ion and indicator dye uptake." Chang, C.-C.; Greaney, M.; Nguyen, M.; Moy, D.; Liu, C.; Dancer, J.; Margerum, L. D., Inorg. Chim. Acta 2014, 409, Part A (0), 127-136.
- "Integrated Laboratory Project Using Cyclic Voltammetry," A. Kulczynska, R. Johnson, T. Frost and L. D. Margerum, J. Chem. Educ., 2011, 88, 801-805.

- "Indicator displacement assays for amino acids using Ni-NTA tethered to PAMAM dendrimers on controlled pore glass," M. J. Greaney, M. A. Nguyen, C.-C. Chang, A. Good and L. D. Margerum, Chem. Commun. (Cambridge, U. K.), 2010, 46, 5337-5339.

- "Effect of PAMAM Dendrimers on *Ru(bpy)32+ Emission Quenching by Ferrocyanide and on ANS Fluorescence: Quantitative Binding Parameters as a Function of Dendrimer Size, pH, and Buffer Composition," Frost, T.; Margerum, L. D. Macromolecules, 2010, 43, 1218-1226.

- "Copper(II) complexes of a biphenyl-based ligand: Tuning the needs of the metal with those of the ligand." Malachowski, M. R.; Kasto, A. S.; Adams, M. E.; Rheingold, A. L.; Zakharov, L. N.; Margerum, L. D.; Greaney, M. Polyhedron, 2009, 28, 393-397.

- "Application of Calibrated Peer Review (CPR) writing assignments to enhance experiments with an environmental chemistry focus," Margerum, L. D.; Gulsrud, M.; Manlapez, R.; Rebong, R.; Love, A., J. Chem. Educ., 2007, 84, 292-294.

- "Synthesis, structure, redox properties and azide binding for a series of biphenyl-based Cu(II) complexes," Chen, J.; Russo, R.; Chao, W.; Margerum, L. D.; Malachowski, M. R.; White, R.; Thawley, Z.; Thayer, A.; Rheingold, A. L.; Zakharov, L. N., Dalton Trans., 2007, 24, 2571-2579.

- "Effect of PAMAM Dendrimer Size and pH on the Electrostatic Binding of Metal Complexes Using Cyclic Voltammetry," Kulczynska, A.; Frost, T.; Margerum, L. D., Macromolecules, 2006, 39, (21), 7372-7377.


Ph.D., University of North Carolina at Chapel Hill

Administrative Appointments

Chair, Chemistry Department