Dr. McGuire's research involves using a biocontextual approach to study children's social and personality development and adjustment during middle childhood and adolescence. She has published papers on twin/sibling similarities and differences in self-concept, personality and loneliness. She has also investigated the nature of children's parent-child and sibling relationships. She received a grant from the National Institute of Mental Health to examine sibling socialization effects and the development of juvenile delinquency and adjustment problems. She is also developing a developmental model of children's computer hacking, a new type of children's behavior problems.
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